Abstract :Abstract
In this investigation the free radical scavenging potential of pyrroloquinoline quinone (PQQ) was consolidated by in-vitro methods. Lipid peroxidation (LPO) was induced by ferrous sulphate (FeSO4), hydrogen peroxide (H2O2) and carbon tetrachloride (CCl4) and then the effects of five different concentrations (10, 20, 40, 80 and 160 µM) of PQQ were evaluated in liver, the major target organ of a drug. While FeSO4, H2O2 and CCl4 markedly enhanced the hepatic LPO; simultaneous administration of PQQ reduced it in a concentration dependent manner. These effects were observed in all three, FeSO4, H2O2 and CCl4 induced hepatic LPO. Out of five different concentrations of PQQ, 20 µM and 80 µM were found most effective, suggesting their beneficial /antioxidative activity. The antioxidative potential of PQQ was thus affirmed by in vitro studies also. We suggest its therapeutic use, particularly in ameliorating oxidative stress associated diseases.